Abstract | BACKGROUND: PATIENTS AND METHODS: Patients with nonmetastatic recurrent disease as manifested by increasing PSA levels (0.4-6.0 ng/mL) and who had undergone previous definitive surgical or radiation therapy were enrolled. Therapy consisted of APC8015 infusion on weeks 0, 2, and 4 (ie, 3 infusions). Prostate-specific antigen was measured at baseline and monthly until disease progression, defined as a doubling of the baseline or nadir PSA value (whichever was lower) to > or = 4 ng/mL or development of distant metastases. RESULTS: Thirteen of 18 patients demonstrated an increase in PSA doubling time (PSADT), with a median increase of 62% (4.9 months before treatment vs. 7.9 months after treatment; P = 0.09; signed-rank test). CONCLUSION:
Therapy was well tolerated. APC8015 as single-agent immunotherapy for patients with ADPC and biochemical progression did not result in > or = 50% decrease in PSA from baseline levels but did appear to modulate PSADT in some patients. Further manipulations of host immunity may be required to achieve a significant antitumor effect.
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Authors | Garth Beinart, Brian I Rini, Vivian Weinberg, Eric J Small |
Journal | Clinical prostate cancer
(Clin Prostate Cancer)
Vol. 4
Issue 1
Pg. 55-60
(Jun 2005)
ISSN: 1540-0352 [Print] United States |
PMID | 15992463
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Prostate-Specific Antigen
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Topics |
- Adenocarcinoma
(immunology, pathology, therapy)
- Aged
- Antigen-Presenting Cells
- Disease Progression
- Humans
- Immunotherapy
(methods)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(immunology, pathology, therapy)
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