Abstract | BACKGROUND: METHODS: HIV-1 DNA levels in PBMCs were determined by quantitative polymerase chain reaction for 383 patients enrolled in the SEROCO Cohort Study who had experienced seroconversion and had been followed up for >8 years. We compared the predictive values of HIV DNA level, HIV RNA level, and CD4+ cell count. RESULTS: Between 6 and 24 months after seroconversion, HIV DNA level was a major predictor of progression to AIDS independently of HIV RNA level and CD4+ T cell count (adjusted relative risk [RR] for a 1-log(10) increase, 3.20 [95% confidence interval {CI}, 1.70-6.00]). HIV DNA level was also a major predictor of disease progression during the first 6 months after seroconversion (adjusted RR, 4.16 [95% CI, 1.70-10.21]), when HIV RNA level and CD4+ T cell count were less predictive. Thus, a combination of these 3 markers provides the best estimate of the risk of disease progression for each patient. CONCLUSIONS: Our results suggest that HIV DNA level could be a useful additional marker in clinical practice and could aid in helping to define the best time to initiate treatment for each patient.
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Authors | Christine Rouzioux, Jean-Baptiste Hubert, Marianne Burgard, Christiane Deveau, Cécile Goujard, Marc Bary, Daniel Séréni, Jean-Paul Viard, Jean-François Delfraissy, Laurence Meyer, SEROCO Cohort Study Group |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 192
Issue 1
Pg. 46-55
(Jul 01 2005)
ISSN: 0022-1899 [Print] United States |
PMID | 15942893
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- DNA, Viral
- RNA, Viral
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Topics |
- Adult
- Biomarkers
- CD4 Lymphocyte Count
- DNA, Viral
(blood)
- Disease Progression
- Female
- HIV Infections
(physiopathology, virology)
- HIV-1
(genetics)
- Humans
- Leukocytes, Mononuclear
(virology)
- Male
- Predictive Value of Tests
- RNA, Viral
(blood)
- Time Factors
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