Vascular endothelial growth factor is regulated by hypoxic stress via MAPK and HIF-1 alpha in the inner ear.

Abstract

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The iron-chelator desferrioxamine (DFX) increased the expression of hypoxia-inducible factor (HIF)-1alpha in the hair cell line, HEI-OC1. The increased VEGF production by DFX was inhibited by iron. DFX also induced the activation of mitogen-activated protein kinase (MAPK) on HEI-OC1. The increased VEGF production by DFX was inhibited by a specific inhibitor of MAPK. In addition, DFX induced the VEGF production and HIF-1alpha stabilization in vivo. These results indicate that VEGF production is regulated via MAPK and HIF-1alpha under hypoxic condition in the inner ear.

• Authors: Hyun-Ja Jeong, Joon-Bae Kim, Seung-Heon Hong, Nyeon-Hyoung An, Min-Sun Kim, Byung-Rim Park, Rae-Kil Park, Hyung-Min Kim
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 163 Issue 1-2 Pg. 84-91 (Jun 2005) ISSN: 0165-5728 [Print] Netherlands
• PMID: 15885310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA-Binding Proteins
• Hif1a protein, mouse
• Hypoxia-Inducible Factor 1
• Hypoxia-Inducible Factor 1, alpha Subunit
• Nuclear Proteins
• Transcription Factors
• Vascular Endothelial Growth Factor A
• Mitogen-Activated Protein Kinases

Topics

• Animals
• Cell Hypoxia (physiology)
• Cell Line
• Cells, Cultured
• DNA-Binding Proteins (physiology)
• Ear, Inner (metabolism)
• Enzyme Activation (physiology)
• Hypoxia-Inducible Factor 1
• Hypoxia-Inducible Factor 1, alpha Subunit
• Mice
• Mice, Transgenic
• Mitogen-Activated Protein Kinases (physiology)
• Nuclear Proteins (physiology)
• Stress, Physiological (metabolism, physiopathology)
• Transcription Factors (physiology)
• Vascular Endothelial Growth Factor A (biosynthesis, genetics)