Abstract | PURPOSE: PATIENTS AND METHODS: Radical prostatectomy specimens from 364 consecutive prostate cancer patients were totally embedded and whole mounted. Various clinical and pathologic characteristics were analyzed. All pathologic data, including Gleason grading variables, were collected prospectively. RESULTS: A multiple-factor analysis was performed that included the combined percentage of Gleason patterns 4 and 5, Gleason score, tumor stage, surgical margin status, preoperative prostate-specific antigen (PSA), extraprostatic extension, and total tumor volume. Using Cox regression analysis with bootstrap resampling for predictor selection, we identified the combined percentage of Gleason patterns 4 and 5 (P < .0001) and total tumor volume (P = .009) as significant predictors of PSA recurrence. CONCLUSION: The combined percentage of Gleason patterns 4 and 5 is one of the most powerful predictors of patient outcome, and appears superior to conventional Gleason score in identifying patients at increased risk of disease progression. On the basis of our results, we recommend that the combined percentage of Gleason patterns 4 and 5 be evaluated in radical prostatectomy specimens. The amount of high-grade cancer in a prostatectomy specimen should be taken into account in therapeutic decision making and assessment of patient prognosis.
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Authors | Liang Cheng, Michael O Koch, Beth E Juliar, Joanne K Daggy, Richard S Foster, Richard Bihrle, Thomas A Gardner |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 23
Issue 13
Pg. 2911-7
(May 01 2005)
ISSN: 0732-183X [Print] United States |
PMID | 15860849
(Publication Type: Journal Article)
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Topics |
- Adenocarcinoma
(pathology, surgery)
- Adult
- Aged
- Disease Progression
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Predictive Value of Tests
- Prognosis
- Prostatectomy
- Prostatic Neoplasms
(pathology, surgery)
- Treatment Outcome
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