A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation.

Abstract

HYPOTHESIS:

Simultaneous administration of mifepristone and misoprostol for medical abortion in women up to 49 days gestation will result in complete abortion in 90% of women within 24 h of treatment.

MATERIALS AND METHODS:

Forty women with pregnancies up to 49 days gestation inserted 800 mug vaginal misoprostol in our office immediately after taking mifepristone 200 mg orally. Follow-up visits, which included vaginal ultrasonography, occurred 24+/-1 h and 2 weeks after treatment. If a gestational sac was still present at the first follow-up visit, the misoprostol dose was repeated. Suction abortion was performed for a viable gestation at the second follow-up visit, presence of a nonviable gestation within 5 weeks of treatment and when clinically indicated.

RESULTS:

Expulsion occurred in 36/40 (90%, 95% CI 80-99) and 39/40 (98%, 95% CI 93-100) women by the first and second follow-up visits, respectively. One woman who had initially expelled the gestational sac after a single dose of misoprostol later required a suction curettage for an incomplete abortion.

CONCLUSION:

Simultaneous administration of mifepristone and vaginal misoprostol is a promising regimen for medical abortion up to 49 days gestation.

• Authors: Amitasrigowri S Murthy, Mitchell D Creinin, Bryna Harwood, Courtney Schreiber
• Journal: Contraception (Contraception) Vol. 71 Issue 5 Pg. 333-6 (May 2005) ISSN: 0010-7824 [Print] United States
• PMID: 15854632 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Abortifacient Agents, Nonsteroidal
• Abortifacient Agents, Steroidal
• Drug Combinations
• Misoprostol
• Mifepristone

Topics

• Abortifacient Agents, Nonsteroidal (administration & dosage)
• Abortifacient Agents, Steroidal (administration & dosage)
• Abortion, Induced
• Administration, Intravaginal
• Adult
• Drug Combinations
• Female
• Humans
• Mifepristone (administration & dosage)
• Misoprostol (administration & dosage)
• Pilot Projects
• Pregnancy
• Pregnancy Trimester, First
• Time Factors