The caspase-8 modulator c-FLIP.

Abstract

Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors. As an important modulator of caspase-8, c-FLIP regulates life and death in various types of normal cells and tissues, such as lymphoid cells, and renders resistance to death receptor-mediated apoptosis in many types of cancer cells. In addition to an apoptosis modulator, c-FLIP has been shown to exert other physiological functions related to cell proliferation and tumorigenesis. Dysregulation of c-FLIP expression has been shown to be associated with various diseases, such as cancer and autoimmune diseases, and c-FLIP might be a critical target for therapeutic intervention. This review focuses on recent findings about the physiological function and intracellular regulation of c-FLIP.

• Authors: Takao Kataoka
• Journal: Critical reviews in immunology (Crit Rev Immunol) Vol. 25 Issue 1 Pg. 31-58 ( 2005) ISSN: 1040-8401 [Print] United States
• PMID: 15833082 (Publication Type: Journal Article, Review)

Chemical References

• CASP8 and FADD-Like Apoptosis Regulating Protein
• CFLAR protein, human
• Intracellular Signaling Peptides and Proteins
• Receptors, Tumor Necrosis Factor
• CASP8 protein, human
• Caspase 8
• Caspases

Topics

• Animals
• Apoptosis (drug effects, immunology, physiology)
• CASP8 and FADD-Like Apoptosis Regulating Protein
• Caspase 8
• Caspases (drug effects, immunology, physiology)
• Humans
• Intracellular Signaling Peptides and Proteins (genetics, pharmacology, physiology)
• Receptors, Tumor Necrosis Factor (antagonists & inhibitors, immunology, physiology)
• Signal Transduction (immunology, physiology)