Abstract | BACKGROUND: OBJECTIVE: METHODS: This study included 55 patients with papulopustular rosacea. Diagnostic efforts were focused on clinical and histological features. Patients were randomly assigned to the adapalene ( n = 30) and metronidazole (n = 25) groups. Sunlight protection factor 20 cream was used to protect all patients from sunlight. The characteristics and numbers of inflammatory papules, pustules, erythema and telangiectasia were scored at baseline and after 2, 4, 8 and 12 weeks. Side-effects were recorded at each visit. RESULTS: Fifty patients, 27 in the adapalene group and 25 in the metronidzaole group, completed the study. Significant reductions in the total number of inflammatory lesions were found in the adapalene group compared with the metronidazole group. There was no significant difference in the scores of erythema and telangiectasia in the adapalene group. However, a significant reduction in erythema was seen in the metronidazole group. CONCLUSIONS:
|
Authors | H Cevdet Altinyazar, Rafet Koca, Nilgün Solak Tekin, Emel Eştürk |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 44
Issue 3
Pg. 252-5
(Mar 2005)
ISSN: 0011-9059 [Print] England |
PMID | 15807740
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Dermatologic Agents
- Gels
- Naphthalenes
- Metronidazole
- Adapalene
|
Topics |
- Adapalene
- Adult
- Aged
- Dermatologic Agents
(therapeutic use)
- Female
- Gels
- Humans
- Male
- Metronidazole
(therapeutic use)
- Middle Aged
- Naphthalenes
(therapeutic use)
- Rosacea
(drug therapy)
- Single-Blind Method
|