HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses.

Abstract

Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case-control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.

• Authors: Robert C Millikan, Amanda J Hummer, Mary S Wolff, Asahi Hishida, Colin B Begg
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 89 Issue 3 Pg. 309-12 (Feb 2005) ISSN: 0167-6806 [Print] Netherlands
• PMID: 15754131 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Codon

Topics

• Adult
• Breast Neoplasms (genetics)
• Case-Control Studies
• Codon
• Cohort Studies
• Female
• Genes, erbB-2
• Genotype
• Humans
• Polymorphism, Genetic
• Risk Factors