Glaucopines A and B, new cyathane diterpenes from the fruiting bodies of Sarcodon glaucopus.

Abstract

Glaucopine A (1) and B (2), two new cyathane diterpenes, have been isolated from the mushroom Sarcodon glaucopus: their structures have been determined on the basis of spectral data. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice: compounds 1 and 2 (1 micromol/cm2) provoked edema reduction (62 % and 55 %, respectively) similar to that induced by the reference non-steroidal anti-inflammatory drug, indomethacin (0.3 micromol/cm2, 61 % edema reduction).

• Authors: Massimo Curini, Federica Maltese, Maria Carla Marcotullio, Luigi Menghini, Rita Pagiotti, Ornelio Rosati, Gianmario Altinier, Aurelia Tubaro
• Journal: Planta medica (Planta Med) Vol. 71 Issue 2 Pg. 194-6 (Feb 2005) ISSN: 0032-0943 [Print] Germany
• PMID: 15729633 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Diterpenes
• Plant Extracts
• cyathane
• Croton Oil

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, pharmacology, therapeutic use)
• Basidiomycota
• Croton Oil
• Diterpenes (administration & dosage, pharmacology, therapeutic use)
• Edema (chemically induced, prevention & control)
• Fruit
• Male
• Mice
• Mice, Inbred Strains
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)