Abstract |
Pharmacokinetic and pharmacodynamic parameters were evaluated after an intravenous administration of torasemide at a dose of 10 mg/kg to control rats and rats with acute renal failure induced by uranyl nitrate (U-ARF). In rats with U-ARF, the total area under the plasma concentration-time curve from time zero to time infinity (AUC) was significantly smaller (6380 versus 4450 microg min/ml) than that in control rats. This was due to significantly faster total body clearance (1.57 versus 2.25 ml/min/kg) in the rats. The faster total body clearance in rats with U-ARF could be due to significantly faster nonrenal clearance (1.51 versus 2.22 ml/min/kg due to faster metabolism) since renal clearance (0.0365 versus 0.00199 ml/min/kg) was significantly slower (due to impaired kidney function) than that in control rats. The 8-h urine output was significantly smaller in rats with U-ARF (178 versus 22.0 ml/kg), however, the 8-h urinary excretion of sodium, potassium, and chloride were not significantly different between two groups of rats.
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Authors | Ae K Lee, Eun J Kim, Myung G Lee |
Journal | Research communications in molecular pathology and pharmacology
(Res Commun Mol Pathol Pharmacol)
Vol. 113-114
Pg. 193-200
( 2003)
ISSN: 1078-0297 [Print] United States |
PMID | 15686118
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Diuretics
- Electrolytes
- Sulfonamides
- Uranyl Nitrate
- Torsemide
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Topics |
- Acute Kidney Injury
(chemically induced, metabolism)
- Animals
- Area Under Curve
- Diuretics
(administration & dosage, pharmacokinetics, pharmacology)
- Electrolytes
(urine)
- Injections, Intravenous
- Male
- Metabolic Clearance Rate
- Rats
- Rats, Sprague-Dawley
- Sulfonamides
(administration & dosage, pharmacokinetics, pharmacology)
- Torsemide
- Uranyl Nitrate
(toxicity)
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