Impact of African herbal medicines on antiretroviral metabolism.

Abstract

We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.

• Authors: Edward Mills, Brian C Foster, Rolf van Heeswijk, Elizabeth Phillips, Kumanan Wilson, Blair Leonard, Kazuhiro Kosuge, Isadore Kanfer
• Journal: AIDS (London, England) (AIDS) Vol. 19 Issue 1 Pg. 95-7 (Jan 03 2005) ISSN: 0269-9370 [Print] England
• PMID: 15627040 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Anti-Retroviral Agents
• Plant Extracts
• Pregnane X Receptor
• Receptors, Cytoplasmic and Nuclear
• Receptors, Steroid
• Verapamil
• Aryl Hydrocarbon Hydroxylases
• Cytochrome P-450 CYP3A
• Oxidoreductases, N-Demethylating

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1 (metabolism)
• Anti-Retroviral Agents (metabolism)
• Aryl Hydrocarbon Hydroxylases (metabolism)
• Cytochrome P-450 CYP3A
• Fabaceae
• Herb-Drug Interactions
• Humans
• Hypoxis
• Oxidoreductases, N-Demethylating (metabolism)
• Phytotherapy (methods)
• Plant Extracts (adverse effects)
• Pregnane X Receptor
• Receptors, Cytoplasmic and Nuclear (metabolism)
• Receptors, Steroid (metabolism)
• Verapamil (metabolism)