Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers.

Abstract

Human DNA polymerases kappa, eta, iota, and zeta are responsible for the translesion DNA synthesis. Numerous in vitro studies indicated that these enzymes may contribute to DNA lesion-triggered and spontaneous mutation. We measured the transcripts of these 4 enzymes in 131 self-paired cancerous and non-tumor samples, including 23 lung cancers, 49 stomach cancers, and 59 colorectal cancers. Our results indicated that, except pol eta in colorectal cancers, these enzymes are all significantly down-regulated in human lung, stomach, and colorectal cancers, suggesting that these enzymes are probably not closely associated with the elevated mutations in human cancer.

• Authors: Qiangrong Pan, Yongming Fang, Yang Xu, Kun Zhang, Xun Hu
• Journal: Cancer letters (Cancer Lett) Vol. 217 Issue 2 Pg. 139-47 (Jan 20 2005) ISSN: 0304-3835 [Print] Ireland
• PMID: 15617831 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA-Directed DNA Polymerase

Topics

• Colorectal Neoplasms (enzymology)
• DNA-Directed DNA Polymerase (metabolism)
• Down-Regulation
• Female
• Humans
• Lung Neoplasms (enzymology)
• Male
• Reverse Transcriptase Polymerase Chain Reaction
• Stomach Neoplasms (enzymology)