Abstract | BACKGROUND: METHODS: Cross-sectional study (The Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994) of the civilian, noninstitutionalized US population. Of the total 33,994 NHANES III participants, those aged 17 years or more and those who had complete urinary albumin-to- creatinine (UAC) ratio information formed our primary study population (n=17,702). The main outcomes of interest were: high serum TC level, defined as levels more than 6.2 mmol/L (240 mg/dL); high serum LDL cholesterol level, defined as levels more that 4.1 mmol/L (160 mg/dL); and low serum HDL cholesterol level, defined as levels less that 0.9 mmol/ L (35 mg/dL). RESULTS: Compared to individuals with normoalbuminuria, the odds ratio (OR) of high serum TC level and high LDL cholesterol level were respectively 1.04 and 1.32 for those with microalbuminuria, and 1.96 and 1.69 for those with macroalbuminuria. Increasing quintiles of UAC ratio was associated with graded increase in the odds of high serum TC (OR, 1,1.23,1.25,1.33,1.46; p trend=0.02) and LDL cholesterol (OR, 1, 0.99, 1.09, 1.46, 1.59; p trend=0.02) levels. In our analyses, the fourth quintile of UAC ratio was associated with significant OR of hypercholesterolemia, despite it being in the currently accepted normal range. However, albuminuria was not associated with low HDL cholesterol in our analysis. CONCLUSIONS:
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Authors | Anoop Shankar, Ronald Klein, Scott E Moss, Barbara E K Klein, Tien Yin Wong |
Journal | Journal of nephrology
(J Nephrol)
2004 Sep-Oct
Vol. 17
Issue 5
Pg. 658-65
ISSN: 1121-8428 [Print] Italy |
PMID | 15593032
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Cholesterol
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Topics |
- Adolescent
- Adult
- Albuminuria
(complications, epidemiology, metabolism)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Female
- Humans
- Hypercholesterolemia
(epidemiology, etiology, metabolism)
- Male
- Middle Aged
- Nutrition Surveys
- Risk Factors
- Socioeconomic Factors
- United States
(epidemiology)
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