Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease.

Abstract

We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.

• Authors: Isabelle Miyazawa, Toshiaki Abe, Koichi Narikawa, Juan Feng, Tatsuro Misu, Ichiro Nakashima, Juichi Fujimori, Makoto Tamai, Kazuo Fujihara, Yasuto Itoyama
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 158 Issue 1-2 Pg. 240-4 (Jan 2005) ISSN: 0165-5728 [Print] Netherlands
• PMID: 15589059 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Chemokines

Topics

• Adolescent
• Adult
• Chemokines (blood, cerebrospinal fluid)
• Enzyme-Linked Immunosorbent Assay (methods)
• Female
• Humans
• Male
• Middle Aged
• Statistics, Nonparametric
• Uveomeningoencephalitic Syndrome (blood, cerebrospinal fluid)