[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2002). III. Secular changes in susceptibility].
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| Abstract |
The bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa) isolated from patients diagnosed as urinary tract infections (UTIs) in 13 institutions in Japan were supplied between August 2002 and July 2003. The susceptibilities of these bacteria to various antimicrobial agents were examined. The bacteria were divided into 2 groups consisting of uncomplicated UTIs and complicated UTIs (with and without indwelling catheter) based on their isolation origins. The results were compared with those obtained between 1993 and 2001. The drug sensitivity of S. aureus in this year was similar to those in up to the previous year and S. aureus showed the best susceptibility to vancomycin. The drug sensitivity of E. faecalis in this year also was similar to those in up to the previous year. The drug sensitivity of E. coli in this year was generally good except penicillins and was similar to those in up to the previous year. Among cephems, cefozopran (CZOP) and cefpirome (CPR) showed the highest potency (MIC90: < or = 0.125 microg/mL). An antibacterial activity of cefotiam (CTM) was similar to it in 10 years ago and was fine (MIC90: < or = 1 microg/mL). The sensitivity of E. coli to carbapenems and carumonam (CRMN) also was good like to CZOP. However, the sensitivity of the complicated UTIs group to quinolones decreased after 2000 and was suggested to develop the resistance to the drug. The drug sensitivity of Klebsiella spp. in this year also was similar to those in up to the previous year. The bacteria showed good susceptibility (MIC: < or = 0.125 microg/mL) to cefmenoxime (CMX), CPR, cefixime (CFIX), flomoxef (FMOX), and CZOP among cephems. The drug sensitivity of P. aeruginosa was generally low. Most of the bacteria were little sensitive to cephems except CZOP and ceftazidime (CAZ). The sensitive bacteria to CZOP and ceftazidime (CAZ) were observed to be 26.8% (15/56 strains) and 39.3% (22/56 strains) in complicated UTIs group, respectively. The sensitivity profile of P. aeruginosa to the other tested drugs was not much different from that in up to the previous year. However, the sensitivity of the bacteria to carbapenems tended to decrease after 2000, and the low sensitive strains (MIC: > or = 256 microg/mL) were detected at 22.2% (2/9 strains) in the uncomplicated UTIs group and 3.6% (2/56 strains) in the complicated UTIs group.
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| Authors | Yoshiaki Kumamoto, Taiji Tsukamoto, Masanori Matsukawa, Yasuharu Kunishima, Takaoki Hirose, Osamu Yamaguti, Kei Ishibashi, Shiro Shigeta, Tatsuo Suzutani, Hiroshi Yoshida, Yuuji Imafuku, Masaru Murai, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi Uchida, Seiji Matsuda, Shinichi Sato, Makoto Fujime, Kazuhiko Fujita, Jun Igari, Toyoko Oguri, Keizo Yamaguchi, Nobuhiko Furuya, Takashi Deguchi, Satoshi Ishihara, Hiroshi Ooe, Mineko Nishikawa, Toshitsugu Oka, Masaya Kitamura, Yoshinori Fukuhara, Sadao Kamidono, Soichi Arakawa, Hiromi Kumon, Koichi Monden, Tetsuro Matsumoto, Koichi Takahashi, Seiji Naito, Toshihisa Egashira, Shigeru Kohno, Yoshitsugu Miyazaki, Yoichi Hirakata, Siho Aoki |
| Journal | The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 57 Issue 4 Pg. 311-403 (Aug 2004) ISSN: 0368-2781 [Print] Japan |
| PMID | 15535040 (Publication Type: Comparative Study, Journal Article, Multicenter Study) |
| Chemical References |
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| Topics |
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