Metronidazole-induced encephalopathy.

Abstract

We report the clinical, neuropsychological, and neuroimaging findings of two patients of diffuse encephalopathy associated with the use of metronidazole. Both patients showed characteristic abnormalities on magnetic resonance imaging (MRI) with diffusion weighted imaging (DWI) and recovered incompletely after the discontinuation of metronidazole. We also suggest that MRI with DWI may be useful in the diagnosis of metronidazole-induced encephalopathy, and that they have a role in the prediction of prognosis.

• Authors: Dong Wook Kim, Jong-Moo Park, Byung-Woo Yoon, Min Jae Baek, Jung Eun Kim, SangYun Kim
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 224 Issue 1-2 Pg. 107-11 (Sep 15 2004) ISSN: 0022-510X [Print] Netherlands
• PMID: 15450780 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents
• Metronidazole

Topics

• Adult
• Anti-Infective Agents (toxicity)
• Attention (physiology)
• Brain Mapping
• Diffusion Magnetic Resonance Imaging (methods)
• Humans
• Male
• Mental Processes (physiology)
• Metronidazole (toxicity)
• Middle Aged
• Neuropsychological Tests (statistics & numerical data)
• Wernicke Encephalopathy (chemically induced, diagnosis, pathology, physiopathology)