Abstract |
The present study assessed the long-term clinical follow-up of 26 of 60 human immunodeficiency virus (HIV)-positive patients who followed structured treatment interruption ( STI) protocols and who, because of good virological response, did not resume receipt of highly active antiretroviral therapy ( HAART). The plasma viral load (pVL) noted after > or =2 years without antiretroviral therapy remained significantly lower than the pVL noted before initiation of HAART, for 11 of the 26 patients (i.e., for 18% of the 60 patients who had STI performed). The CD4+ T cell count remained stable throughout the study. A low pVL at the end of follow-up was independently associated with a low CD8+CD38+ T lymphocyte count and a high stimulation index to p24 antigen after STI. In conclusion, approximately 2 years after STI, only a low proportion of patients who had a good immunological profile at the end of the STI period still had a good virological response.
|
Authors | Eric Florence, Felipe García, Montserrat Plana, Emilio Fumero, Pedro Castro, Anna Lopez, Anna Cruceta, Cristina Gil, Mireia Arnedo, José M Miró, Tomás Pumarola, Teresa Gallart, José M Gatell |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 39
Issue 4
Pg. 569-74
(Aug 15 2004)
ISSN: 1537-6591 [Electronic] United States |
PMID | 15356824
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adult
- Antiretroviral Therapy, Highly Active
(methods)
- Chronic Disease
- Drug Administration Schedule
- Female
- Follow-Up Studies
- HIV Infections
(drug therapy)
- HIV-1
(drug effects)
- Humans
- Male
- Pulse Therapy, Drug
(methods)
- Time
- Treatment Outcome
- Viral Load
|