N-Acetyltransferase 2 gene polymorphism in a group of senile dementia patients in Shanghai suburb.

Abstract

AIM:

To investigate the possible association of hereditary polymorphism of N-acetyltransferase 2 (NAT2) gene with the susceptibility towards senile dementia in farmer population of Shanghai suburb.

METHODS:

NAT2 gene genotyping was performed at 7 major polymorphic loci (G191A, C282T, T341C, C481T, G590A, A803G, and G857A) with a polymerase chain reaction-based restriction fragment length polymorphism based procedure in 2 groups of farmer subjects in Shanghai suburb. A group of 51 diagnosed dementia patients [comprising 29 sporadic Alzheimer disease (AD) patients and 22 sporadic vascular dementia (VD) patients] and a group of 112 healthy individuals were in the same area.

RESULTS:

The homogenous rapid genotypes (R/R, including*4/*4, *13 /*13, and *4/*13) was found over-present in both groups of patients, compared with healthy individuals, for all farmer dementia patients, 52.9 % vs 33.0 %, P=0.016, OR (95 % CI): 2.28(1.16-4.48); for AD group only, 51.7 % vs 33.0 %, P=0.063, OR (95 % CI): 2.18 (0.95-4.97); for VD group 54.5 % vs 33.0 %, P=0.055, OR (95 % CI): 2.43 (0.96-2.43). The significant frequency difference of genotype *4/*7B between farmer dementia patients and healthy individuals, and that of solo-alleles *13, and *7B were observed between the healthy individuals and both groups of dementia patients.

CONCLUSION:

Our data suggest the involvement of various NAT2 rapid-acetylating genotypes in the individual susceptibility to senile dementia. Variant genotypes of NAT2 might serve as a hereditary risk factor for AD and VD in Chinese population.

• Authors: Wei-Chao Guo, Guo-Fang Lin, Yong-Lin Zha, Ke-Jian Lou, Qing-Wen Ma, Jian-Hua Shen
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 25 Issue 9 Pg. 1112-7 (Sep 2004) ISSN: 1671-4083 [Print] United States
• PMID: 15339384 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Arylamine N-Acetyltransferase
• NAT2 protein, human

Topics

• Aged
• Aged, 80 and over
• Alleles
• Alzheimer Disease (genetics)
• Arylamine N-Acetyltransferase (genetics)
• Asian People
• China
• Dementia, Vascular (genetics)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Risk Factors