[A case of hepatic metastasis from colon cancer successfully treated with 5-FU, levofolinate (l-LV) and low-dose CPT-11].

The patient was a 67-year-old man in whom hepatic metastasis from transverse colon cancer was detected 15 months after transverse colectomy (D2). We treated the patient by systemically administering 2 courses of 5-FU 750 mg/day with l-LV 350 mg/day (once weekly for 6 weeks per course). Assessment of therapeutic effects by CT showed PD in the patient. As a second-line therapy, we treated the patient by systemically administering 3 courses of 5-FU 750 mg/day, l-LV 350 mg/day and CPT-11 40 mg/day x 3 days (once a week for 4 weeks per course). After 3 courses of this chemotherapy, CT examination revealed a reduction in the tumor size of the liver, and CEA levels decreased at the end of this chemotherapy. This chemotherapy also showed no high-grade toxicities. l-LV/5-FU/low-dose CPT-11 seems to be effective for metastatic colon cancer, and safe from the toxicity standpoint.
AuthorsOsamu Harada, Makoto Kobayashi, Makoto Sasamoto, Sen Shimaya
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 31 Issue 8 Pg. 1245-7 (Aug 2004) ISSN: 0385-0684 [Print] Japan
PMID15332552 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • irinotecan
  • Leucovorin
  • Fluorouracil
  • Camptothecin
  • Adenocarcinoma (drug therapy, secondary, surgery)
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Camptothecin (administration & dosage, analogs & derivatives)
  • Chemotherapy, Adjuvant
  • Colectomy
  • Colonic Neoplasms (drug therapy, pathology, surgery)
  • Drug Administration Schedule
  • Fluorouracil (administration & dosage)
  • Humans
  • Leucovorin (administration & dosage)
  • Liver Neoplasms (drug therapy, secondary)
  • Male
  • Remission Induction

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