Abstract | AIM: METHODS: Forty-three children who had undergone both 99mTc-EC and 99mTc-DMSA studies within 5 days of acute infection were studied. Cortical images of 99mTc-EC were obtained by the sum of the renogram frames achieved between the first 60-120 s of the renogram study. DMSA and EC images were visually interpreted using four points of semiquantitative ratings: 0, normal; 1, mild hypoactivity; 2, moderate hypoactivity with partial loss of margins; 3, marked hypoactivity with loss of cortical margins. Values for the differential renal function were obtained for both studies. RESULTS:
DMSA detected a total of 109 lesions in 36 patients and EC detected 90 lesions with a sensitivity of 82.5%. 99mTc-EC successfully detected moderate-to-severe cortical lesions but was less effective with mild lesions (sensitivity 60%). Bland-Altman analysis demonstrated good agreement among the results for differential renal function (95% CI -0.26 to 0.96). CONCLUSION: 99mTc-EC early phase images detected most of the cortical lesions. Its sensitivity depends on the severity of the lesions. EC provided reliable information in the estimation of differential renal function.
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Authors | Tamer Atasever, Ozan Ozkaya, Evrim Abamor, Oğuz Söylemezoğlu, Necla Buyan, Mustafa Unlü |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 25
Issue 9
Pg. 967-70
(Sep 2004)
ISSN: 0143-3636 [Print] England |
PMID | 15319604
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Validation Study)
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Chemical References |
- Organotechnetium Compounds
- Radiopharmaceuticals
- technetium Tc 99m-ethylenedicysteine
- Technetium Tc 99m Dimercaptosuccinic Acid
- Cysteine
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Topics |
- Child
- Child, Preschool
- Cysteine
(analogs & derivatives)
- Female
- Humans
- Infant
- Kidney Cortex
(diagnostic imaging)
- Kidney Function Tests
(methods)
- Kidney Papillary Necrosis
(classification, diagnosis, diagnostic imaging)
- Male
- Organotechnetium Compounds
- Radioisotope Renography
(methods)
- Radiopharmaceuticals
- Reproducibility of Results
- Sensitivity and Specificity
- Severity of Illness Index
- Technetium Tc 99m Dimercaptosuccinic Acid
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