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Succimer (Dimercaptosuccinic Acid)

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.

Also Known As:

Dimercaptosuccinic Acid; DMSA; 2,3 Dimercaptosuccinic Acid; Chemet; 2,3-Dimercaptosuccinic Acid; Ro-1-7977; SERB Brand of Succimer; Sanofi Brand of Succimer; Succicaptal; Succimer Antimony Sodium Salt, (R*,S*)-Isomer; Succimer, (R*,R*)-(+,-)-Isomer; Succimer, Dipotassium Salt; Succimer, Disodium Salt; Succimer, Monosodium Salt; Succimer, Rhenium Salt; Succimer, Tin Salt; Tin Dimercaptosuccinate; meso-Dimercaptosuccinic Acid; Dimercaptosuccinate, Tin; Dipotassium Salt Succimer; Disodium Salt Succimer; Monosodium Salt Succimer; Rhenium Salt Succimer; Ro 1 7977; Ro17977; Tin Salt Succimer; meso Dimercaptosuccinic Acid; Butanedioic acid, 2,3-dimercapto-, (R*,S*)-

Networked: 963 relevant articles (71 outcomes, 156 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Sulfur Compounds: 135
  - Sulfhydryl Compounds: 637
    - Succimer: 963
- Carboxylic Acids: 83
  - Acyclic Acids
    - Dicarboxylic Acids: 76
      - Succinic Acids: 3
        Succimer: 963
        Technetium Tc 99m Dimercaptosuccinic Acid: 216
        stibocaptate: 36
        monoisoamyl-2,3-dimercaptosuccinate: 11
        rhenium(V)dimercaptosuccinic acid: 2
        2,3-dimercaptosuccinic acid monocyclohexyl ester
        2,3-dimercaptosuccinic acid-cysteine (1-2) mixed disulfide
        di-(isoamyl)dimercaptosuccinate
        di-(isobutyl)dimercaptosuccinate
        diethyl dimercaptosuccinate
        diisopropyl 2,3-dimercaptosuccinate
        dimercaptosuccinic acid monomethyl ester
        dimethyl mercaptosuccinate
        monobenzyl 2,3-dimercaptosuccinate
        monohexyl 2,3-dimercaptosuccinate

Experts

1.	Tsiouris, Spyridon: 9 articles (10/2011 - 01/2004)
2.	Flora, S J S: 7 articles (07/2013 - 01/2003)
3.	Papantoniou, Vassilios: 7 articles (10/2011 - 01/2005)
4.	Mahyar, Abolfazl: 6 articles (12/2015 - 03/2011)
5.	Sotiropoulou, Maria: 6 articles (10/2011 - 07/2004)
6.	Ayazi, Parviz: 5 articles (12/2015 - 03/2011)
7.	Hoberman, Alejandro: 5 articles (07/2015 - 01/2003)
8.	Sheu, Ji-Nan: 5 articles (03/2013 - 12/2006)
9.	Chen, Shan-Ming: 5 articles (03/2013 - 12/2006)
10.	Chen, Mei-Ju: 5 articles (01/2013 - 07/2003)

Related Diseases

1.	Cicatrix (Scar) 04/01/2015 - "PAR images generated from a dynamic renal scintigraphy improved sensitivity of detection of renal scars as compared with SUM images, providing a high reproducibility and diagnostic efficacy, similar to that of Tc-99m DMSA, in detection of post-inflammatory renal scarring." 11/01/2012 - "Dimercaptosuccinic acid imaging is the 'gold standard' for the detection of cortical defects and diagnosis of scarring of the kidneys. " 05/01/2009 - "DMSA scintigraphy was regarded as the gold standard for the diagnosis of renal scarring. " 08/01/2007 - "Accuracy of ultrasonic detection of renal scarring in different centres using DMSA as the gold standard." 02/01/2004 - "Ultrasonography in the evaluation of renal scarring using DMSA scan as the gold standard."
2.	Lead Poisoning (Poisoning, Lead) 02/01/1996 - "To determine whether succimer (meso-2,3-dimercaptosuccinic acid) would be effective in reducing blood lead concentration in dogs with naturally acquired lead poisoning and whether treated dogs would develop clinically important adverse effects. " 08/01/1994 - "Renal clearance of total DMSA was greater in healthy adults (77.0 +/- 13.2 ml/min per square meter) than in either adults (24.7 +/- 3.3 ml/min per square meter) or children with lead poisoning (16.6 ml/min per square meter); renal clearance of the metabolites of DMSA was also greater in healthy adults (64.6 +/- 10.1 ml/min per square meter) than in either adults (35.4 +/- 8.4 ml/min per square meter) or children with lead poisoning (19.5 ml/min per square meter). " 01/01/1992 - "We conclude that a 5-day oral course of DMSA is effective in the treatment of children with severe lead poisoning. " 06/01/1998 - "The aim of this study was to evaluate the efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) treatment in workers with increased lead absorption and no overt symptoms of lead poisoning. " 02/01/1996 - "In dogs with naturally acquired lead poisoning, succimer administered orally for 10 days effectively reduced blood lead concentrations and eliminated clinical signs of lead poisoning."
3.	Poisoning 11/01/1978 - "The data indicate that DMSA might be effective in protecting the developing organism against morphological and/or behavioral teratological consequences of methylmercury poisoning in utero." 04/01/2000 - "Succimer is considered to be a safe and effective treatment for lead (Pb) poisoning, since it reduces body Pb levels without an apparent diuresis of other essential elements. " 02/01/2007 - "The present study was designed to answer these questions, using a rodent model of early childhood Pb exposure and treatment with succimer, a widely used chelating agent for the treatment of Pb poisoning. " 02/01/1996 - "DMSA seems to be promising in the treatment of occupational Pb poisoning. " 07/01/1995 - "The oral availability and relative safety of DMSA presents the controversial option of treating patients with Pb poisoning on an outpatient basis. "
4.	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 07/01/2011 - "To evaluate the accuracy of acute-phase DMSA scanning in identifying dilating (grades III through V) vesicoureteral reflux documented by VCUG in children with a first febrile UTI, we performed a meta-analysis of the accuracy of diagnostic tests as reported from relevant studies identified through the PubMed and Scopus databases. " 01/01/2009 - "In these studies, vesico-ureteral reflux was diagnosed by voiding cystourethrogram and kidney damage was assessed by either DMSA scan or urography. " 06/01/2004 - "The objective of this study was to evaluate the usefulness of DMSA scintigraphy performed during UTI as a predictor of patient outcome, to identify children at risk of events [vesico-ureteral reflux (VUR) or recurrent UTI] that may lead to the development of progressive renal damage. " 11/01/2003 - "The study included 43 children investigated by DMSA and IVU, who had vesicoureteral reflux diagnosed and classified through voiding cystourethrography. " 09/01/1998 - "Five-year study of medical or surgical treatment in children with severe vesico-ureteral reflux dimercaptosuccinic acid findings. "
5.	Arsenic Poisoning 01/01/2005 - "DMSA could be a safe and effective method for treating lead or arsenic poisoning, but one of the major disadvantages of chelation with DMSA has been its inability to remove lead from the intracellular sites because of its lipophobic nature. " 01/01/2003 - "The efficacy of monoisoamyl ester of dimercaptosuccinic acid in chronic experimental arsenic poisoning in mice." 05/01/2007 - "Slow recovery from severe inorganic arsenic poisoning despite treatment with DMSA (2.3-dimercaptosuccinic acid)." 09/16/2005 - "To address this problem, analogs of DMSA having lipophilic character, were examined against chronic arsenic poisoning in experimental animals. " 01/01/2001 - "Intentional overdose of dimercaptosuccinic acid in the course of treatment for arsenic poisoning."

Related Drugs and Biologics

1.	Succimer (Dimercaptosuccinic Acid)
2.	Technetium Tc 99m Dimercaptosuccinic Acid
3.	Unithiol (DMPS)
4.	Pentetic Acid (DTPA)
5.	ferric oxide (iron oxide)
6.	Doxorubicin (Adriamycin)
7.	monoisoamyl-2,3-dimercaptosuccinate
8.	arsenic trioxide (Trisenox)
9.	lewisite
10.	Chelating Agents

Related Therapies and Procedures

1.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
2.	Chelation Therapy (Therapy, Chelation)
3.	Nephrectomy
4.	Intravenous Injections
5.	Drug Therapy (Chemotherapy)