Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.

Abstract

This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.

• Authors: Juan C Hernández, Francisco León, José Quintana, Francisco Estévez, Jaime Bermejo
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 12 Issue 16 Pg. 4423-9 (Aug 15 2004) ISSN: 0968-0896 [Print] England
• PMID: 15265493 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Icogenin
• Saponins
• Steroids
• Poly(ADP-ribose) Polymerases

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Apoptosis
• Dracaena (chemistry)
• HL-60 Cells
• Humans
• Poly(ADP-ribose) Polymerases (metabolism)
• Saponins (chemistry, isolation & purification, pharmacology, toxicity)
• Steroids (chemistry, isolation & purification, toxicity)