[Axillary lymph node involvement in hormone-independent breast carcinomas].

Abstract

BACKGROUND AND OBJECTIVE:

We decided to study the axillary lymph node invasion (N) in hormone-independent breast cancer.

PATIENTS AND METHOD:

The study group included 77 ER and 47 ER/PgR breast carcinomas. Both ER and PgR were determined using EIAS from Abbott (USA).

RESULTS:

In ER tumors, one the most important finding was the high concentration (p = 0.001) and percentage of positives ( > 50 pmol/mg prot.; 24/41 vs 7/36; p < 0.01) of cathepsin D observed in N+ vs N- tumors. In ER/PgR negative tumors, lymph node involvement was associated with a same behavior of this proteinase (p = 0.021; 17/31 vs 2/16; p = 0.006) exclusively.

CONCLUSIONS:

Our results point to a possible usefulness of cathepsin D in this type of carcinomas.

• Authors: Alvaro Ruibal, José Ignacio Arias
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 123 Issue 2 Pg. 50-2 (Jun 12 2004) ISSN: 0025-7753 [Print] Spain
• Vernacular Title: Invasión de los ganglios axilares en el carcinoma mamario con receptores hormonales negativos.
• PMID: 15225483 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Receptors, Estrogen
• Receptors, Progesterone
• Cathepsin D

Topics

• Adult
• Aged
• Axilla
• Biomarkers (analysis)
• Breast Neoplasms (metabolism, pathology)
• Carcinoma, Ductal, Breast (metabolism, secondary)
• Cathepsin D (metabolism)
• Female
• Humans
• Lymphatic Metastasis
• Middle Aged
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)