Effect of intraperitoneal administration of docetaxel on peritoneal dissemination of gastric cancer.
|
| Abstract |
The effect of intraperitoneal (i.p.) administration of docetaxel was evaluated for preclinical evidence of anticancer activity in athymic mice bearing a gastric cancer cell line, MKN-45-P that shows a high rate of metastasis to the peritoneal cavity of nude mice. Nude mice were inoculated i.p. with 10(7) MKN-45-P cells. On days 2, 5, 9, 12, 16 and 19 after tumor inoculation, mice were treated with i.p. injection of docetaxel. Treatment doses of docetaxel were 8 mg/kg (N = 7) 2 mg/kg (N = 7) and 0.5 mg/kg (N = 7). Intraperitoneal carcinoembryonic antigen (CEA) levels, animal body weight, mortality and survival were determined. All control mice developed ascites and died within 19-40 days. The median survival time in the control group was 32 days, while those of mice treated with 8, 2 and 0.5 mg/kg were 90, 63 and 49.5 days, respectively. One of seven mice treated with 8 mg/kg of docetaxel died of toxicity on day 12. Four mice were tumor-free on day 90, but two had tumors in the abdomen when autopsied on day 90. One mouse treated with 2 mg/kg was ascertained to be tumor-free on day 90. All seven mice treated with 0.5 mg/kg of docetaxel died of peritoneal dissemination within 71 days. The results suggest the potential of intraperitoneal docetaxel administration for the treatment of peritoneal dissemination of gastric cancer.
|
|---|---|
| Authors | Yutaka Yonemura, Yoshio Endou, Etsurou Bando, Kiyoshi Kuno, Taiichi Kawamura, Masashi Kimura, Tsutomu Shimada, Ken-Ichi Miyamoto, Takuma Sasaki, Paul H Sugarbaker |
| Journal | Cancer letters (Cancer Lett) Vol. 210 Issue 2 Pg. 189-96 (Jul 16 2004) ISSN: 0304-3835 [Print] Ireland |
| PMID | 15183534 (Publication Type: Journal Article) |
| Copyright | Copyright 2004 Elsevier Ireland Ltd. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!