Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction.

Abstract

BACKGROUND:

Cyclooxygenase-2 (COX-2) has been reported to play an important role in the pathogenesis of a variety of cancers. Little is known about the relationship between bile duct cancer associated with pancreaticobiliary maljunction (PBM) and COX-2.

MATERIALS AND METHODS:

We compared the expression of COX-2 in bile duct epithelium in bile duct cancer with or without PBM.

RESULTS:

Immunohistochemical analysis showed that the rate of positive COX-2 expression was 42.9% for cancerous lesions and 7.1% for noncancerous lesions in cases of bile duct cancer without PBM. On the other hand, no positive expression of COX-2 was observed in cancerous lesion of bile duct cancer with PBM. Twenty % of the noncancerous bile duct mucosa with PBM was positive for COX-2.

CONCLUSION:

COX-2 is expressed in bile duct cancer while it is not expressed in bile duct cancer accompanied by PBM.

• Authors: Osamu Watanabe, Kazuhiko Yoshimatsu, Shunichi Shiozawa, Akira Tsuchiya, Nobuyuki Oshibe, Motohiko Aiba, Kenji Ogawa
• Journal: Anticancer research (Anticancer Res) 2004 Mar-Apr Vol. 24 Issue 2B Pg. 671-4 ISSN: 0250-7005 [Print] Greece
• PMID: 15161010 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• Membrane Proteins
• Cyclooxygenase 2
• PTGS2 protein, human
• Prostaglandin-Endoperoxide Synthases

Topics

• Aged
• Bile Duct Neoplasms (complications, enzymology, pathology)
• Choledochal Cyst (complications, enzymology)
• Cyclooxygenase 2
• Epithelium (enzymology)
• Female
• Humans
• Immunohistochemistry
• Isoenzymes (biosynthesis)
• Male
• Membrane Proteins
• Neoplasm Staging
• Prostaglandin-Endoperoxide Synthases (biosynthesis)