High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD).

Abstract

The aim of the present study was to evaluate the role of a weekly preoperative chemotherapy in locally advanced, unresectable gastric cancer. In all, 82 patients with an Eastern Oncology Cooperative Group PS <or=2 and normal cardiac function were enrolled onto the study. Surgical unresectability was confirmed in 52 patients (63%) at laparotomy, and in 30 (27%) cases by CT scan of the abdomen and endoscopic ultrasonography. Chemotherapy treatment was: cisplatin 40 mg x m(-2); 5-fluorouracil 500 mg x m(-2); epidoxorubicin 35 mg x m(-2); 6S-leucovorin 250 mg x m(-2) and glutathione 1.5 g x m(-2) (PELF). One cycle consisted of 8 weekly treatments. Response to chemotherapy was observed in 40 of 82 patients (49%): six (7%) complete and 34 (41%) partial responses, and in four (5%) cases a complete pathological response was confirmed. Of the 40 responding patients, 37 (45%) had potentially curative surgery. Grade 3/4 leucopenia and thrombocytopenia occurred in three and two patients. At a median follow-up of 48 months, 25 of the 37 resected patients (68%) were alive and 24 (65%) were disease free. The median and 4-year survival for the whole group was 17 months and 31%, respectively. The median survival was 12 months for inoperable patients and it was not reached in resected patients.

• Authors: S Cascinu, M Scartozzi, R Labianca, V Catalano, R R Silva, S Barni, A Zaniboni, A D'Angelo, S Salvagni, G Martignoni, G D Beretta, F Graziano, R Berardi, V Franciosi, Italian Group for the Study of Digestive Tract Cancer (GISCAD)
• Journal: British journal of cancer (Br J Cancer) Vol. 90 Issue 8 Pg. 1521-5 (Apr 19 2004) ISSN: 0007-0920 [Print] England
• PMID: 15083179 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• Epirubicin
• Levoleucovorin
• Glutathione
• Filgrastim
• Cisplatin
• Leucovorin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, therapeutic use)
• Cisplatin (administration & dosage)
• Disease-Free Survival
• Drug Administration Schedule
• Epirubicin (administration & dosage)
• Female
• Filgrastim
• Fluorouracil (administration & dosage)
• Glutathione (administration & dosage)
• Granulocyte Colony-Stimulating Factor (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Leukopenia (chemically induced)
• Levoleucovorin
• Male
• Middle Aged
• Neoadjuvant Therapy
• Recombinant Proteins
• Stomach Neoplasms (drug therapy, pathology)
• Thrombocytopenia (chemically induced)
• Treatment Outcome