The efficacy and tolerability of barnidipine hydrochloride in Thai patients with hypertension.

Abstract

This open-label, blinded study was performed to evaluate the efficacy and tolerability of barnidipine at a titrated dose of 10-15 mg once daily for 8 weeks in the treatment of essential hypertension in 40 Thai patients. 'Office' blood pressure (BP) and 24-h ambulatory BP measurements were recorded. A systolic BP/diastolic BP (SBP/DBP) reduction of 18.0 +/- 13.6/9.1 +/- 6.6 mmHg was obtained. The full response rate among patients with systolic and diastolic hypertension was 63% using either SBP or DBP criteria, and 54% using both SBP and DBP criteria. One of the two patients with isolated systolic hypertension had a full response, and the BP in two of the three patients with isolated diastolic hypertension was normalized. The trough-to-peak ratio and smoothness index for SBP/DBP were acceptable (0.76 +/- 0.63/0.55 +/- 0.26 and 1.2 +/- 0.4/1.2 +/- 0.3, respectively). In conclusion, once-daily barnidipine monotherapy provides effective 24-h BP control and is generally well tolerated in ambulatory patients.

• Authors: P Buranakitjaroen, B Koanantakul, M Phoojaroenchanachai, C Chawantanpipat
• Journal: The Journal of international medical research (J Int Med Res) 2004 Mar-Apr Vol. 32 Issue 2 Pg. 185-200 ISSN: 0300-0605 [Print] England
• PMID: 15080023 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Blockers
• Placebos
• mepirodipine
• Nifedipine

Topics

• Adult
• Aged
• Blood Pressure Monitoring, Ambulatory
• Calcium Channel Blockers (therapeutic use)
• Female
• Humans
• Hypertension (drug therapy, physiopathology)
• Male
• Middle Aged
• Nifedipine (analogs & derivatives, therapeutic use)
• Placebos
• Single-Blind Method
• Thailand