99mTc-HMPAO distribution at SPECT is associated with succinate-cytochrome c reductase (SCR) activity in subjects with psychiatric disorders.

Abstract

The origin of altered (99m)Tc-HMPAO distribution at SPECT in psychiatric disorders is unknown. Correlations between brain (99m)Tc-HMPAO distribution and muscle succinate-cytochrome c reductase (SCR, complex II + III) were assessed in 20 unmedicated psychiatric patients. Significant negative correlations were found between (99m)Tc-HMPAO distribution in associative sensory regions and SCR activity. Sensory cortices are normally enriched in complex II activity. The production of electrons and reactive oxygen species affecting the redox state is considered to be highest from complex III, but complex II may also contribute. The negative relationship between (99m)Tc-HMPAO uptake and SCR activity may be due to redox state alterations influencing fixation of the radiopharmaceutical.

• Authors: Ann Gardner, Marco Pagani, Henning Beier, Hans Jacobsson, Stig A Larsson, Tore Hällström
• Journal: Nuclear medicine and biology (Nucl Med Biol) Vol. 31 Issue 2 Pg. 277-82 (Feb 2004) ISSN: 0969-8051 [Print] United States
• PMID: 15013494 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Validation Study)

Chemical References

• Radiopharmaceuticals
• Technetium Tc 99m Exametazime
• Succinate Cytochrome c Oxidoreductase

Topics

• Adult
• Brain (diagnostic imaging, metabolism)
• Female
• Humans
• Male
• Mental Disorders (diagnostic imaging, metabolism)
• Mitochondria, Muscle (enzymology)
• Muscle, Skeletal (enzymology)
• Radiopharmaceuticals (pharmacokinetics)
• Statistics as Topic
• Succinate Cytochrome c Oxidoreductase (metabolism)
• Technetium Tc 99m Exametazime (pharmacokinetics)
• Tissue Distribution
• Tomography, Emission-Computed, Single-Photon (methods)