[Therapeutic drug monitoring of cyclosporine MEPC (Neoral) therapy for interstitial pneumonia].

Abstract

It is widely recognized that the area under the concentration-time curve (AUC) correlates with the clinical effects of cyclosporine MEPC (Neoral) therapy and adverse reactions to it. In this study, we investigated which single blood-level measurement had correlated best with AUC in interstitial pneumonia therapy. Neoral was prescribed in ten cases of interstitial pneumonia. We measured the concentration during the 4 hours following its administration and calculated AUC0-4 (AUC 0-4 hr). The concentration after 2 hours of administration (C2) correlated best with AUC (r2 = 0.71). This result suggests that C2 monitoring would be a better predictor for AUC than C0 (trough level) monitoring in interstitial pneumonia therapy.

• Authors: Tetsuro Inoue, Eisaku Tanaka, Terufumi Kato, Minoru Sakuramoto, Masayoshi Minakuchi, Yuji Maeda, Ko Maniwa, Kunihiko Terada, Yoshio Taguchi
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 42 Issue 2 Pg. 153-7 (Feb 2004) ISSN: 1343-3490 [Print] Japan
• PMID: 15007915 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Administration, Oral
• Aged
• Cyclosporine (administration & dosage, blood)
• Drug Monitoring (methods)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage, blood)
• Lung Diseases, Interstitial (drug therapy)
• Male
• Middle Aged
• Time Factors