[Informative value of the parameter "effective concentration of albumin" in diffuse peritonitis: data from a multi-center study].

Abstract

The paper represents data on new potentialities in evaluating a severity of patients with total peritonitis (TP). They are based on the fluorescence analysis of the physical-and-chemical properties of blood albumin. The findings are a result of a multi-center research undertaken by clinics of Moscow and Moscow Region. The properties of albumin-molecule binding sites were investigated by the fluorescence test. The parameter, measured in the test, was named "effective albumin concentration". The study protocol comprised the data of clinical examinations, scales SAPS and MPI as well as laboratory findings and EAC. The subsequent analysis denoted that a combination of 2 parameters, i.e. EAC and serum urea concentration routinely measured, is highly informative in evaluating the TP severity and correlates well with the survival rate in the discussed pathology. The study results could be a basis for an early individual prognostication of TP course made on the 1st postoperative day.

• Authors: Iu A Gryzunov, A A Grinberg, V A Stupin, G V Rodoman, S G Musselius, N M Fedorovskiĭ, G E Dobretsov, T I Chernysh, T I Shalaeva, V I Par
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2003 Nov-Dec Issue 6 Pg. 32-5 ISSN: 0201-7563 [Print] Russia (Federation)
• Vernacular Title: Informativnost' pokazatelia "éffektivnaia kontsentratsiia al'bumina" pri rasprostranennom peritonite: dannye mnogotsentrovogo issledovaniia.
• PMID: 14991977 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Fluorescent Dyes
• Serum Albumin
• Urea

Topics

• Fluorescent Dyes
• Fluorometry
• Humans
• Moscow
• Peritonitis (blood, diagnosis, mortality, surgery)
• Prognosis
• Retrospective Studies
• Serum Albumin (analysis)
• Survival Analysis
• Urea (blood)