Increased remission of early stage membranous nephropathy on long-term treatment with corticosteroid.

Abstract

Sixty-five patients with primary membranous nephropathy were examined in order to assess the effects of long-term treatment with corticosteroid. The observation period varied from 8 to 279 months (average, 95 months). The patients were treated with corticosteroid alone or with combinations of corticosteroid and immunosuppressants, nonsteroidal anti-inflammatory drugs (NSAID) and/or dipyridamole. At 6 months after treatment, only 14% of the patients had achieved complete remission. At 24 months after treatment, 46% of the patients showed complete remission. The rate of clinical remission, i.e. complete and incomplete remission, was markedly increased in stage I and II patients with membranous nephropathy by Ehrenreich and Churg's classification but not in stage III patients. The actuarial survival curve indicated that 84% of the patients were alive at 10 years after onset. These data suggest that active treatment with corticosteroid is beneficial for patients with primary membranous nephropathy.

• Authors: K Funabiki, Y Tomino, I Shirato, M Yoshida, H Koide
• Journal: Nihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 34 Issue 9 Pg. 997-1001 (Sep 1992) ISSN: 0385-2385 [Print] Japan
• PMID: 1479738 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Immunosuppressive Agents
• Dipyridamole
• Prednisolone

Topics

• Adolescent
• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Dipyridamole (administration & dosage)
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Glomerulonephritis, Membranous (drug therapy, mortality)
• Humans
• Immunosuppressive Agents (administration & dosage)
• Male
• Middle Aged
• Prednisolone (administration & dosage)
• Remission Induction
• Survival Rate
• Time Factors