[Use of guinea pigs for assessing the efficacy of vaccines against Lassa fever].

Abstract

The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the vaccines developed against Lassa fever at the preclinical study stage. An adapted variant of Lassa virus was cultivated, which caused death of guinea pigs with respect for an agent's dose. Finally, it was shown to be possible to investigate the immunogenic and protective properties of the inactivated antigen of Lassa virus in experiments with guinea pigs.

• Authors: I V Firsova, I V Shatokhina, I V Borisevich, A A Evseev, V A Maksimov, V B Pantiukhov, A L Khmelev
• Journal: Voprosy virusologii (Vopr Virusol) 2003 Nov-Dec Vol. 48 Issue 6 Pg. 43-5 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Ispol'zovanie morskikh svinok dlia otsenki éffektivnosti vaktsin protiv likhoradki Lassa.
• PMID: 14708232 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Viral
• Viral Vaccines

Topics

• Animals
• Antigens, Viral (immunology)
• Female
• Guinea Pigs
• Lassa Fever (prevention & control)
• Lassa virus (immunology)
• Male
• Viral Vaccines (administration & dosage, immunology)