Abstract | BACKGROUND: METHODS: Over a 4-month period, the authors studied 33 chronic obstructive pulmonary disease patients with acute exacerbation who were admitted to four intensive care units and treated with helmet NPPV. The patients were compared with 33 historical controls treated with FM NPPV, matched for simplified acute physiologic score (SAPS II), age, PaCO2, pH, and PaO2:fractional inspired oxygen tension. The primary endpoints were the feasibility of the technique, improvement of gas exchange, and need for intubation. RESULTS: The baseline characteristics of the two groups were similar. Ten patients in the helmet group and 14 in the FM group (P = 0.22) were intubated. In the helmet group, no patients were unable to tolerate NPPV, whereas five patients required intubation in the FM group (P = 0.047). After 1 h of treatment, both groups had a significant reduction of PaCO2 with improvement of pH; PaCO2 decreased less in the helmet group (P = 0.01). On discontinuing support, PaCO2 was higher (P = 0.002) and pH lower (P = 0.02) in the helmet group than in the control group. One patient in the helmet group, and 12 in the FM group, developed complications related to NPPV (P < 0.001). Length of intensive care unit stay, intensive care unit, and hospital mortality were similar in both groups. CONCLUSIONS:
|
Authors | Massimo Antonelli, Mariano Alberto Pennisi, Paolo Pelosi, Cesare Gregoretti, Vincenzo Squadrone, Monica Rocco, Luca Cecchini, Davide Chiumello, Paolo Severgnini, Rodolfo Proietti, Paolo Navalesi, Giorgio Conti |
Journal | Anesthesiology
(Anesthesiology)
Vol. 100
Issue 1
Pg. 16-24
(Jan 2004)
ISSN: 0003-3022 [Print] United States |
PMID | 14695719
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Acidosis, Respiratory
(physiopathology)
- Acute Disease
- Aged
- Carbon Dioxide
(blood, metabolism)
- Endpoint Determination
- Feasibility Studies
- Female
- Humans
- Intubation, Intratracheal
- Male
- Masks
- Monitoring, Physiologic
- Positive-Pressure Respiration
(instrumentation)
- Pulmonary Disease, Chronic Obstructive
(complications, therapy)
- Respiratory Function Tests
- Treatment Outcome
- Ventilator Weaning
|