Curvularia--favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis.

Abstract

Curvularia species are ubiquitous and occasionally lead to infections in humans. In immunosuppressed patients, infections are often serious, and systemic dissemination is not uncommon. The optimal antifungal therapy is unclear. I here present two cases, a healthy man with locally invasive, mulicentric paranasal fungal sinusitis, and a case of progressive verrucal distal onychomycosis that developed while the patient was undergoing accelerated chemotherapy for non-Hodgkin's lymphoma. Both patients showed excellent responses to treatment with itraconazole suspension. Oral itraconazole may provide a safe and effective alternative for patients with locally invasive non-disseminated mycoses due to Curvularia species.

• Authors: A Safdar
• Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (Clin Microbiol Infect) Vol. 9 Issue 12 Pg. 1219-23 (Dec 2003) ISSN: 1198-743X [Print] England
• PMID: 14686987 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Itraconazole

Topics

• Administration, Oral
• Adult
• Antifungal Agents (administration & dosage, therapeutic use)
• Ascomycota (growth & development)
• Humans
• Immunocompromised Host
• Itraconazole (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Mycoses (drug therapy)
• Onychomycosis (drug therapy, microbiology)
• Sinusitis (drug therapy, microbiology)