[Determination of the stable mitochondrial factor in vivo].

Abstract

We have determined a release of a stable mitochondrial factor (SMF) into the outflowing blood in vivo. That effect was induced by ischemia/reperfusion or phenylarsin oxide (PAO)--the activators of the mitochondrial permeability transition pore (MPTP) and the oxidative stress. The SMF was measured by a spectrophotometer in the range of wave-lengths 230-260 nm with the absorption maximum of 240-250 nm. The SMF release was accompanied with a decrease in the myocardial contractility, disturbances in cardiodynamics and regional blood circulation. The data obtained have demonstrated that the SMF can be used as a marker of MPTP opening in vivo.

• Authors: S M Nadtochiĭ, A Iu Bohuslavs'kyĭ, V F Sahach
• Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) (Fiziol Zh (1994)) Vol. 49 Issue 5 Pg. 25-30 ( 2003) ISSN: 2522-9028 [Print] Ukraine
• Vernacular Title: Vyznachennia stabil'noho faktora mitokhondrial'noho pokhodzhennia in vivo.
• PMID: 14663887 (Publication Type: Journal Article)

Chemical References

• Arsenicals
• Biomarkers
• Ion Channels
• Mitochondrial Membrane Transport Proteins
• Mitochondrial Permeability Transition Pore
• Mitochondrial Proteins
• oxophenylarsine

Topics

• Animals
• Arsenicals (pharmacology)
• Biomarkers (blood)
• Coronary Circulation (physiology)
• Dogs
• Hindlimb (blood supply)
• Ion Channels (metabolism)
• Mitochondrial Membrane Transport Proteins
• Mitochondrial Permeability Transition Pore
• Mitochondrial Proteins (blood)
• Myocardial Contraction (physiology)
• Myocardial Reperfusion Injury (blood, metabolism, physiopathology)
• Oxidative Stress (drug effects, physiology)
• Regional Blood Flow (physiology)