Quantification of Ile-Ser-Bradykinin degradation in human serum and ascites.

Abstract

A leucine aminopeptidase (LAP) and a carboxypeptidase (CP) activity in human serum and malignant ascites degrade Ile-Ser-Bradykinin (ISB = T-Kinin) in two catalytic steps to desArg9Bradykinin. The catalytic activity in serum is always higher than in ascites. In serum the carboxypeptidase activity is higher than the LAP activity whereas in ascites the two activities are not different.

• Authors: J Rehbock, C Steinhauser, A Hermann
• Journal: Agents and actions. Supplements (Agents Actions Suppl) Vol. 38 ( Pt 1) Pg. 449-53 ( 1992) ISSN: 0379-0363 [Print] Switzerland
• PMID: 1466292 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• T-kinin
• Carboxypeptidases
• Leucyl Aminopeptidase
• Bradykinin

Topics

• Amino Acid Sequence
• Ascites (metabolism)
• Binding Sites
• Bradykinin (analogs & derivatives, blood, chemistry, metabolism)
• Carboxypeptidases (blood, metabolism)
• Female
• Humans
• Leucyl Aminopeptidase (blood, metabolism)
• Molecular Sequence Data
• Ovarian Neoplasms (blood, metabolism)
• Uterine Cervical Neoplasms (blood, metabolism)