Stereostructure of komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp. KS3.

Abstract

The absolute stereostructure of komodoquinone A (1), a neuritogenic anthracycline, which was isolated from a cultured marine Streptomyces sp. KS3, has been determined on the basis of chemical derivatization. Komodoquinone A (1) induces neuronal cell differentiation in the neuroblastoma cell line, Neuro 2A and arrests the cell cycle at the G1 phase. The effect of a solid-state medium on the production of 1 and its aglycone, komodoquinone B (2), was examined.

• Authors: Takuya Itoh, Masahiro Kinoshita, Hong Wei, Motomasa Kobayashi
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 51 Issue 12 Pg. 1402-4 (Dec 2003) ISSN: 0009-2363 [Print] Japan
• PMID: 14646317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthracyclines
• Anthraquinones
• komodoquinone A

Topics

• Animals
• Anthracyclines (chemistry, isolation & purification, pharmacology)
• Anthraquinones (chemistry, isolation & purification, pharmacology)
• Cell Cycle (drug effects, physiology)
• Cell Line, Tumor
• Fermentation
• Mice
• Seawater (microbiology)
• Stereoisomerism
• Streptomyces (chemistry, growth & development)