Abstract | BACKGROUND: METHODS: Human breast cancer ZR-75-1 xenografts were used as model in nude mice. RESULTS:
EM-652 not only prevented estrogen-induced tumor growth but it reduced tumor size to 20% of the pretreatment value. Complete disappearance of the tumors was observed in 65% (106/163) of tumors. No tumor progressed. Most importantly, 93% of the tumors which had become undetectable under EM-652 treatment did not reappear when exposed to estrogen challenge for 12 weeks, thus achieving an overall 61% cure rate. CONCLUSIONS:
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Authors | Jenny Roy, Steeve Couillard, Mathieu Gutman, Fernand Labrie |
Journal | Breast cancer research and treatment
(Breast Cancer Res Treat)
Vol. 81
Issue 3
Pg. 223-9
(Oct 2003)
ISSN: 0167-6806 [Print] Netherlands |
PMID | 14620917
(Publication Type: Journal Article)
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Chemical References |
- Estrogens, Non-Steroidal
- Piperidines
- Selective Estrogen Receptor Modulators
- ritetronium
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Topics |
- Analysis of Variance
- Animals
- Breast Neoplasms
(drug therapy, prevention & control)
- Carcinoma
(drug therapy, prevention & control)
- Estrogens, Non-Steroidal
(pharmacology)
- Female
- Humans
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Piperidines
(pharmacology)
- Recurrence
- Remission Induction
- Selective Estrogen Receptor Modulators
(pharmacology)
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