Abstract | BACKGROUND: Pancreatic surgery is not uncommonly complicated by prolonged pancreatic drainage and fistula. Octreotide decreases pancreatic exocrine function and has been reported to improve closure of pancreatic and intestinal fistulae. This randomized, prospective trial was designed to evaluate the efficacy of postoperative octreotide in reducing pancreatic drainage and complications after resection of neuroendocrine tumors of the pancreas. METHODS: Patients with neuroendocrine tumors of the pancreas were entered into the study and randomized after operation to receive octreotide 150 micrograms subcutaneously every 8 hours or saline solution subcutaneously every 8 hours in a double-blinded fashion. Daily pancreatic drainage, total drainage, number of days to drain removal, and complications were recorded. RESULTS: Ten patients were given octreotide; eleven patients were given saline solution. The number of days to drain removal, daily drainage, and total drainage were not significantly different. Complications related to pancreatic drainage were not significantly different. CONCLUSIONS:
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Authors | J R Lange, S M Steinberg, G M Doherty, H N Langstein, D E White, T H Shawker, R C Eastman, R T Jensen, J A Norton |
Journal | Surgery
(Surgery)
Vol. 112
Issue 6
Pg. 1033-7; discussion 1037-8
(Dec 1992)
ISSN: 0039-6060 [Print] United States |
PMID | 1455306
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aged
- Double-Blind Method
- Drainage
- Endocrine Gland Neoplasms
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Nervous System Neoplasms
(drug therapy)
- Octreotide
(therapeutic use)
- Pancreatic Neoplasms
(drug therapy)
- Postoperative Care
- Postoperative Complications
- Prospective Studies
- Time Factors
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