The effect of FK664, a new cardiovascular drug, on systemic capacitance vessels in anesthetized dogs.

Abstract

To characterize the cardiovascular effect of FK664, a compound developed for the treatment of heart failure, the mean circulatory pressure (MCP), cardiac output and other parameters were measured in open-chest anesthetized dogs. Milrinone, a cardiotonic agent, and nifedipine, a calcium channel blocker were used as reference substances. Nifedipine (10 micrograms/kg), FK664 (0.1 mg/kg) or milrinone (0.1 mg/kg) given intravenously reduced the total peripheral resistance in a similar extent (35-40%). Whereas nifedipine had no effect on MCP, FK664 produced a significant decrease in MCP. Milrinone caused a minimal decrease in MCP, but not significantly. These results indicate that FK664 dilates the systemic capacitance vessels. This action to reduce the pre-load would be beneficial in the treatment of heart failure.

• Authors: Y Sudo, K Esumi
• Journal: Life sciences (Life Sci) Vol. 51 Issue 25 Pg. PL261-5 ( 1992) ISSN: 0024-3205 [Print] Netherlands
• PMID: 1453874 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cardiotonic Agents
• Pyridones
• Pyrimidinones
• FK 664
• Nifedipine
• Milrinone

Topics

• Animals
• Blood Vessels (drug effects)
• Cardiac Output (drug effects)
• Cardiotonic Agents (pharmacology)
• Dogs
• Hemodynamics (drug effects)
• Injections, Intravenous
• Milrinone
• Nifedipine (pharmacology)
• Pyridones (pharmacology)
• Pyrimidinones (pharmacology)
• Vascular Resistance (drug effects)