[1st successful immunization of pancreas and colorectal carcinoma patients with CO17-1A-vaccine].

Abstract

The baculovirus-derived extracellular domain of the CO17-1A antigen induced cellular and/or humoral immune responses in curatively resected colorectal and pancreatic cancer patients after at least three applications of the vaccine. The vaccine application was safe and non-toxic. The clinical efficacy of the vaccine needs to be evaluated in larger, randomized clinical trials.

• Authors: L Staib, H Braumüller, C Leeser, H G Beger, R Somasundaram, W Li, B Birebent, D Herlyn
• Journal: Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress (Langenbecks Arch Chir Suppl Kongressbd) Vol. 115 Issue Suppl I Pg. 53-8 ( 1998) ISSN: 0942-2854 [Print] Germany
• Vernacular Title: Erste erfolgreiche Immunisierung von Pankreas- und kolorektalen Karzinompatienten mit CO17-1A-Vakzin.
• PMID: 14518212 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Clinical Trial, Phase II, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Neoplasm
• Antigens, Neoplasm
• Cancer Vaccines
• Cell Adhesion Molecules
• Epithelial Cell Adhesion Molecule
• Vaccines, DNA
• carcinoma-associated antigen 17-1A

Topics

• Aged
• Antibodies, Neoplasm (blood)
• Antigens, Neoplasm (immunology)
• Cancer Vaccines (immunology, therapeutic use)
• Cell Adhesion Molecules (immunology)
• Colorectal Neoplasms (immunology, surgery)
• Combined Modality Therapy
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Epithelial Cell Adhesion Molecule
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Pancreatic Neoplasms (immunology, surgery)
• Vaccines, DNA (immunology, therapeutic use)