Treatment of Paget's disease of bone with mithramycin.

Abstract

The hypothesis that Paget's disease of bone is a low grade neoplastic process led us to use the cytotoxic antibiotic mithramycin in its treatment. The dramatic effects observed on the serum calcium and alkaline phosphatase, and urinary hydroxyproline are compatible with the concept that mithramycin is primarily toxic to osteoclasts. Subjective and objective clinical effects establish this agent as useful in the treatment of Paget's disease despite its observed toxicity to other organ systems.

• Authors: W G Ryan
• Journal: Clinical orthopaedics and related research (Clin Orthop Relat Res) Issue 127 Pg. 106-10 ( 1977) ISSN: 0009-921X [Print] United States
• PMID: 144039 (Publication Type: Journal Article)

Chemical References

• Plicamycin

Topics

• Chemical and Drug Induced Liver Injury
• Humans
• Kidney Diseases (chemically induced)
• Osteitis Deformans (drug therapy)
• Plicamycin (adverse effects, therapeutic use)
• Thrombocytopenia (chemically induced)