Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women.

Abstract

Vaginal concentrations of mannose-binding lectin (MBL) and possession of a polymorphism in codon 54 of the MBL gene were determined in 42 women with recurrent vulvovaginal candidiasis (RVVC) and 43 control subjects. Reduced vaginal MBL levels and an increased occurrence of the polymorphism were present in women with RVVC.

• Authors: Oksana Babula, Gunta Lazdane, Juta Kroica, William J Ledger, Steven S Witkin
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 37 Issue 5 Pg. 733-7 (Sep 01 2003) ISSN: 1537-6591 [Electronic] United States
• PMID: 12942410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Codon
• Mannose-Binding Lectin

Topics

• Adolescent
• Adult
• Candida albicans (drug effects, isolation & purification)
• Candidiasis, Vulvovaginal (diagnosis, genetics, metabolism)
• Codon (genetics)
• Female
• Genetic Predisposition to Disease (genetics)
• Humans
• Latvia (epidemiology)
• Mannose-Binding Lectin (genetics, metabolism)
• Polymorphism, Genetic (genetics)
• Recurrence