Antiasthmatic activity of the methanol extract of leaves of Passiflora incarnata.

Abstract

The methanol extract of the leaves of P. incarnata was evaluated for its antiasthmatic effects against acetylcholine chloride (Ach)-induced-bronchospasm in guinea-pigs at doses of 50, 100 and 200 mg/kg. Using a 7-day treatment regimen, significant prevention of dyspnoea-related-convulsions was noted in the animals treated with a 100 mg/kg dose of this extract. No preventive effect was exhibited by the 50 mg/kg dose and at a higher dose, i.e. 200 mg/kg, the preventive effects against Ach-chloride-induced-dyspnoea were also reduced. This may be due to defective alpha-adrenoceptor function reported after excessive or continuous administration of an alpha-receptor agonist.

• Authors: Kamaldeep Dhawan, Suresh Kumar, Anupam Sharma
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 17 Issue 7 Pg. 821-2 (Aug 2003) ISSN: 0951-418X [Print] England
• PMID: 12916087 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 John Wiley & Sons, Ltd.

Chemical References

• Anti-Asthmatic Agents
• Plant Extracts
• Acetylcholine

Topics

• Acetylcholine
• Animals
• Anti-Asthmatic Agents (administration & dosage, pharmacology, therapeutic use)
• Bronchial Spasm (chemically induced, prevention & control)
• Dose-Response Relationship, Drug
• Female
• Guinea Pigs
• Male
• Passiflora
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Plant Leaves