Abstract | OBJECTIVES: STUDY DESIGN: Prospective and ex vivo. METHODS: RESULTS:
MMP levels were highest in APTO, and HNE was highest in chronic suppurative OM and APTO. High levels of MMP and HNE (>3 mAU/min) were found in 52% and 37% of MEEs, respectively. Ilomastat and rAAT demonstrated significant inhibition of MMP and HNE activity (>30% reduction), respectively, in 80% and 82% of MEEs with high levels of activity. CONCLUSIONS:
Proteases are commonly found in OM. Ilomastat and rAAT are potent inhibitors of proteases in MEEs across a wide range of OM in humans. Investigation into the potential therapeutic benefits of these protease inhibitors is warranted.
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Authors | Patrick J Antonelli, Gregory S Schultz, Karen M Kim, John S Cantwell, David J Sundin, Philip A Pemberton, Philip J Barr |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 113
Issue 8
Pg. 1347-51
(Aug 2003)
ISSN: 0023-852X [Print] United States |
PMID | 12897557
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxamic Acids
- Indoles
- Inflammation Mediators
- Matrix Metalloproteinase Inhibitors
- Serine Proteinase Inhibitors
- alpha 1-Antitrypsin
- Leukocyte Elastase
- Matrix Metalloproteinases
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- ilomastat
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Topics |
- Adolescent
- Adult
- Child, Preschool
- Chronic Disease
- Female
- Humans
- Hydroxamic Acids
- In Vitro Techniques
- Indoles
(pharmacology)
- Inflammation Mediators
(metabolism)
- Leukocyte Elastase
(antagonists & inhibitors, metabolism)
- Male
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(metabolism)
- Otitis Media with Effusion
(enzymology)
- Otitis Media, Suppurative
(enzymology)
- Recurrence
- Serine Proteinase Inhibitors
(pharmacology)
- alpha 1-Antitrypsin
(pharmacology)
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