Adenosine extracellular levels in human brain gliomas: an intraoperative microdialysis study.

Abstract

Adenosine present in human brain glioma extracellular spaces is a marker of astrocyte purine metabolism. In this study, we evaluated adenosine levels in the extracellular fluid of 21 human gliomas of high-grade malignancy using brain microdialysis techniques coupled to high-performance liquid chromatography. The adenosine concentration (mean+/-SEM) within the control tissue was 2.99+/-0.37 microM and in the tumour tissue 1.56+/-0.46 microM. The reduction was statistically significant. It is concluded that the adenosine concentrations reached in the tumour tissue are sufficient to stimulate all adenosine receptor subtypes, suppress local anti-tumour immune responses and affect glial and endothelial cell proliferation.

• Authors: Alessia Melani, Enrico De Micheli, Giampietro Pinna, Alex Alfieri, Laura Della Corte, Felicita Pedata
• Journal: Neuroscience letters (Neurosci Lett) Vol. 346 Issue 1-2 Pg. 93-6 (Jul 31 2003) ISSN: 0304-3940 [Print] Ireland
• PMID: 12850556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adenosine

Topics

• Adenosine (metabolism)
• Adult
• Aged
• Brain Neoplasms (metabolism, surgery)
• Chromatography, High Pressure Liquid (methods)
• Extracellular Space (metabolism)
• Female
• Glioma (metabolism, surgery)
• Humans
• Intraoperative Period (methods)
• Male
• Microdialysis (methods)
• Middle Aged