Primary intestinal posttransplant T-cell lymphoma.

Abstract

There have been only five reported cases of primary posttransplant T-cell lymphoma. We report the first case associated with the use of sirolimus (Rapamycin, Wyeth-Ayerst, Philadelphia, PA). The patient, receiving prednisone, cyclosporine, and sirolimus treatment, developed ascites, diarrhea, and weight loss 7 months after his second renal transplant. Tissue obtained at laparotomy established the diagnosis of primary T-cell lymphoma. Latent membrane protein-1 for Epstein-Barr virus was negative, but in-site hybridization test for Epstein-Barr-encoded RNA was positive. Despite aggressive chemotherapy, the patient died 8 months posttransplant. This is the sixth reported case of primary intestinal posttransplant T-cell lymphoma, but it is the first case associated with the use of sirolimus. The incidence of posttransplant lymphoproliferative disease in patients receiving sirolimus should be studied.

• Authors: J Michael, S Greenstein, R Schechner, V Tellis, L V Vasovic, H Ratech, D Glicklich
• Journal: Transplantation (Transplantation) Vol. 75 Issue 12 Pg. 2131-2 (Jun 27 2003) ISSN: 0041-1337 [Print] United States
• PMID: 12829924 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Immunosuppressive Agents
• Sirolimus

Topics

• Fatal Outcome
• Humans
• Immunosuppressive Agents (adverse effects)
• Intestinal Neoplasms (chemically induced, pathology)
• Kidney Transplantation (immunology)
• Lymphoma, T-Cell (chemically induced, pathology)
• Male
• Middle Aged
• Postoperative Complications (pathology)
• Sirolimus (adverse effects)