Effects of protease inhibitors in experimental septic shock.

Abstract	Endotoxin shock and contact system activation were used to study effects of hirudin, antithrombin III, eglin C, aprotinin, and [Arg15]-aprotinin in anesthetized pigs. Alterations in the systemic and pulmonary circulation were in part prevented by administration of the inhibitors.
Authors	M Siebeck, M Spannagl, H Hoffmann, E Fink
Journal	Agents and actions. Supplements (Agents Actions Suppl) Vol. 38 ( Pt 3) Pg. 421-7 ( 1992) ISSN: 0379-0363 [Print] Switzerland
PMID	1281381 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Hirudins Lipopolysaccharides Protease Inhibitors Proteins Recombinant Proteins Serine Proteinase Inhibitors Serpins eglin proteinase inhibitors Dextran Sulfate Aprotinin
Topics	Animals Aprotinin (pharmacokinetics, pharmacology, therapeutic use) Dextran Sulfate Hirudin Therapy Hirudins (pharmacology) Lipopolysaccharides Protease Inhibitors (pharmacology) Proteins Recombinant Proteins (pharmacology) Serine Proteinase Inhibitors (pharmacology, therapeutic use) Serpins Shock, Septic (chemically induced, drug therapy, physiopathology) Swine Swine, Miniature

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