Abstract | BACKGROUND: METHODS: Six subjects polysomnographically diagnosed as obstructive sleep apnea syndrome and 10 controls were included. After all subjects gave written informed consent, blood samples were collected in the morning between 08:00 and 09:00 a.m. following polysomnography. Blood samples were immediately transferred to the laboratory. Glutathione, lipid peroxidation and osmotic fragility of red blood cells were measured manually. RESULTS: Mean glutathione and lipid peroxidation concentrations of patients were not different than those of control subjects (105.6+/-38.6 U/g Hb and 3.1+/-2.3 nmol MDA/l vs. 100.6+/-62.1 U/g Hb and 3.2+/-2.8 nmol MDA/l, respectively). In both groups, osmotic fragility of red blood cells was not changed. CONCLUSION: The present study failed to support the hypothesis that obstructive sleep apnea is linked with increased oxidative stress and lipid peroxidation.
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Authors | Levent Oztürk, Banu Mansour, Meral Yüksel, A Süha Yalçin, Firuz Celikoğlu, Nuran Gökhan |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 332
Issue 1-2
Pg. 83-8
(Jun 2003)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 12763284
(Publication Type: Journal Article)
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Chemical References |
- Oxyhemoglobins
- Reactive Oxygen Species
- Glutathione
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Topics |
- Body Mass Index
- Female
- Glutathione
(blood)
- Humans
- Lipid Peroxidation
- Male
- Middle Aged
- Osmotic Fragility
- Oxidative Stress
- Oxyhemoglobins
(analysis, metabolism)
- Polysomnography
- Reactive Oxygen Species
(blood)
- Reproducibility of Results
- Sleep Apnea, Obstructive
(blood, metabolism)
- Sleep Stages
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