Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats.

Abstract

The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma). The methanol extract (250 and 500 mg/kg(-1) p.o.) exhibited significant activity (p < 0.001) against all phlogistic agents used in a dose dependant manner. In the chronic model (cotton pouch granuloma method) the methanol extract exhibited significant anti-inflammatory activity. All these effects were compared with standard drug phenylbutazone (100 mg/kg(-1) p.o.).

• Authors: U K Mazumder, M Gupta, L Manikandan, S Bhattacharya, P K Haldar, S Roy
• Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 10 Issue 2-3 Pg. 185-8 (Mar 2003) ISSN: 0944-7113 [Print] Germany
• PMID: 12725574 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Plant Extracts
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Carrageenan
• Edema (chemically induced, drug therapy)
• Female
• Forelimb (drug effects, pathology)
• Male
• Phytotherapy
• Plant Extracts (pharmacology)
• Rats
• Rats, Wistar
• Vernonia